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2023 Journal CME: Does prophylactic local tobramycin injection lower open fracture infection rates?

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Accreditation Statement: The Orthopaedic Trauma Association (OTA) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation:  OTA designates this enduring material for a maximum of 1 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Learning Objectives

After completing this activity, learners will be able to:

  1. Administer the correct dosage of Tobramycin for a patient with an open extremity fracture according to the study design as outlined in the aforementioned paper.
  2. Describe the inclusion and exclusion criteria for patients considered for the new tobramycin study.


  • Author: Arun Aneja, MD, and Chandler R. Sneed

Original release date: 3/31/2023

Expiration date: 3/31/2024

Estimated time to complete activity: 1 hour

Statement of Need/Description/or Summary of Gap Analysis

Evidence has shown that local antibiotics given in addition to systemic antibiotics lead to lower fracture-related infection (FRI) rates. Still, FRIs remain a significant cause of disability among military and civilian personnel who have sustained an open fracture. The goal of this multicenter RCT is to further support the use of local antibiotics, specifically tobramycin, in the treatment of open extremity fractures, potentially propagating its use as the standard of care in addition to systemic antibiotics.

Instructional Format: This Orthopaedic Trauma Association International Journal CME activity consists of a journal article, a quiz, and an evaluation.

Method of Participation: There are no fees for members to participate in this activity. Non-members must pay $30. This online activity consists of an article, a self-assessment exam, and an evaluation. To receive AMA PRA Category 1 Credit™ credit, participants must read the journal article, successfully complete the post-test quiz, and achieve a minimum score of 75% on the quiz. The quiz includes 4 multiple choice questions. Learners will be asked to read each question, select an answer, and review the section of the article where the answer is found. Learners will be able to review the content and repeat the quiz as many times as needed. Upon achieving a score of 75% or higher, learners will be asked to complete a post-activity evaluation. A certificate of credit or participation will be available upon successful submission of the post-activity evaluation.


The Orthopaedic Trauma Association has implemented a policy to comply with the current Accreditation Council for Continuing Medical Education (ACCME) Standards for Integrity and Independence in Accredited Continuing Education requiring mitigation of all conflicts of interest. Faculty declaring a relevant commercial interest must be identified in the activity syllabus and/or program.

In accordance with disclosure policies of OTA and the ACCME, every effort has been made to ensure all CME activities are balanced, independent, objective, and scientifically rigorous. These policies include complying with ACCME’s Standards for Integrity and Independence in Accredited Continuing Education and mitigating all relevant conflicts of interest for all individuals in control of content.  

All of the relevant financial relationships listed for these individuals have been mitigated

All disclosures are available on the "Disclosure" tab.

Disclaimer: The information in this educational activity is provided for general medical education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient's medical condition. The viewpoints expressed in this CME activity are those of the authors/faculty. They do not represent an endorsement by the OTA.  In no event will the OTA be liable for any decision made or action taken in reliance upon the information provided through this CME activity.

Commercial Support: There is no commercial support for this activity


Read the CME Article
Open to download resource.
Open to download resource. Please read the OTAI Journal CME Article by downloading the attached PDF.
4 Questions  |  Unlimited attempts  |  3/4 points to pass
4 Questions  |  Unlimited attempts  |  3/4 points to pass Please complete the following multiple-choice quiz. You must achieve 75% or higher to pass.
8 Questions
8 Questions Please complete the activity evaluation to claim CME credit for this course.
CME Certificate
Up to 1.00 medical credits available  |  Certificate available
Up to 1.00 medical credits available  |  Certificate available